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terminal half-life 20-50 minutes) with a steady-state volume approximating total extracellular fluid, findings that justify loading schedules followed by less frequent injections once tissue stores exceed 2 mg

The process is based on an absorption gradient high at site of injection and low in the blood

Several simple strategies exist to create meaningful improvements in vitamin B12 absorption

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Previous work has shown that the abundance of Lactobacillus reuteri (normalized to a control group) decreases during the onset of obesity and remains suppressed even after dieting in mice 99 , which parallels our observations that vehicle-treated diet-switched mice had lower levels of Lactobacillus than the 5A-1MQ-treated mice, the latter of which also demonstrated greater weight loss

Available from: Heffernan MA, Thorburn AW, Fam B, et al